Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357043187> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2357043187 abstract "Objective:To assess the safety and pharmacokinetic profile of levofloxacin.Method:4 male and 6 female healthy subjects at 48～56 years of age were i.v.given with a single dose of lev-ofloxacin (500mg).Blood and urine samples from the tested subjects were collected at fixed schedulesto assay levofloxacin concentrations in plasma and urine samples by a validated HPLC.Results:Thepharmacokinetic profile of levofloxacin was coincident with a two-compartment open model,and themain parameters were as follows:C_(max)=(9.03±1.92)mg·L~(-1),t_(1/2)β=(7.99±1.69)h,V_d=(1.24±0.31)L·kg~(-1),CL/F=(11.64±2.51)L·h~(-1),AUC=(44.79±9.05)mg·h·L~(-1),and therenal clearance rate was (76.78±9.07)% within 24 hours.Levofloxacin was well tolerated.Conclu-sion:No significant discrepancy between the Chinese population and Western population was found inthe pharmacokinetic parameters.Highly dosing of levofloxacin may offer an option in the treatment ofsevere infections and the infections that are unresponsive well to other antibiotics." @default.
- W2357043187 created "2016-06-24" @default.
- W2357043187 creator A5047160347 @default.
- W2357043187 date "2004-01-01" @default.
- W2357043187 modified "2023-09-26" @default.
- W2357043187 title "Pharmacokinetics of single 500-milligram doses of intravenous levofloxacin in middle-age healthy volunteers" @default.
- W2357043187 hasPublicationYear "2004" @default.
- W2357043187 type Work @default.
- W2357043187 sameAs 2357043187 @default.
- W2357043187 citedByCount "0" @default.
- W2357043187 crossrefType "journal-article" @default.
- W2357043187 hasAuthorship W2357043187A5047160347 @default.
- W2357043187 hasConcept C112705442 @default.
- W2357043187 hasConcept C126322002 @default.
- W2357043187 hasConcept C185592680 @default.
- W2357043187 hasConcept C2777288759 @default.
- W2357043187 hasConcept C2778049240 @default.
- W2357043187 hasConcept C2778512257 @default.
- W2357043187 hasConcept C2780026642 @default.
- W2357043187 hasConcept C2781276175 @default.
- W2357043187 hasConcept C2908647359 @default.
- W2357043187 hasConcept C3019249092 @default.
- W2357043187 hasConcept C501593827 @default.
- W2357043187 hasConcept C55493867 @default.
- W2357043187 hasConcept C71924100 @default.
- W2357043187 hasConcept C90924648 @default.
- W2357043187 hasConcept C98274493 @default.
- W2357043187 hasConcept C99454951 @default.
- W2357043187 hasConceptScore W2357043187C112705442 @default.
- W2357043187 hasConceptScore W2357043187C126322002 @default.
- W2357043187 hasConceptScore W2357043187C185592680 @default.
- W2357043187 hasConceptScore W2357043187C2777288759 @default.
- W2357043187 hasConceptScore W2357043187C2778049240 @default.
- W2357043187 hasConceptScore W2357043187C2778512257 @default.
- W2357043187 hasConceptScore W2357043187C2780026642 @default.
- W2357043187 hasConceptScore W2357043187C2781276175 @default.
- W2357043187 hasConceptScore W2357043187C2908647359 @default.
- W2357043187 hasConceptScore W2357043187C3019249092 @default.
- W2357043187 hasConceptScore W2357043187C501593827 @default.
- W2357043187 hasConceptScore W2357043187C55493867 @default.
- W2357043187 hasConceptScore W2357043187C71924100 @default.
- W2357043187 hasConceptScore W2357043187C90924648 @default.
- W2357043187 hasConceptScore W2357043187C98274493 @default.
- W2357043187 hasConceptScore W2357043187C99454951 @default.
- W2357043187 hasLocation W23570431871 @default.
- W2357043187 hasOpenAccess W2357043187 @default.
- W2357043187 hasPrimaryLocation W23570431871 @default.
- W2357043187 hasRelatedWork W175500087 @default.
- W2357043187 hasRelatedWork W1973361029 @default.
- W2357043187 hasRelatedWork W1981551849 @default.
- W2357043187 hasRelatedWork W2009670691 @default.
- W2357043187 hasRelatedWork W2013033899 @default.
- W2357043187 hasRelatedWork W2034941908 @default.
- W2357043187 hasRelatedWork W2069512513 @default.
- W2357043187 hasRelatedWork W2097126290 @default.
- W2357043187 hasRelatedWork W2169675659 @default.
- W2357043187 hasRelatedWork W2349400912 @default.
- W2357043187 hasRelatedWork W2378800729 @default.
- W2357043187 hasRelatedWork W2408168840 @default.
- W2357043187 hasRelatedWork W2413362074 @default.
- W2357043187 hasRelatedWork W2414102040 @default.
- W2357043187 hasRelatedWork W2416249700 @default.
- W2357043187 hasRelatedWork W3006365185 @default.
- W2357043187 hasRelatedWork W3009119877 @default.
- W2357043187 hasRelatedWork W3087997842 @default.
- W2357043187 hasRelatedWork W2404720116 @default.
- W2357043187 hasRelatedWork W2779398325 @default.
- W2357043187 isParatext "false" @default.
- W2357043187 isRetracted "false" @default.
- W2357043187 magId "2357043187" @default.
- W2357043187 workType "article" @default.