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- W2357068699 abstract "Objective To observe the neuroprotective effect of emodin in rats with cranio-cerebral explosive wound. Methods 66 SD rats were randomly divided into 3 groups (each n = 30),normal control group,model control group,and emodin group. Cranio-cerebral explosive rat models were established in model control group and emodin group,then rats in model control group received normal saline peritoneal injection,while rats in emodin group received 10 mg / (kg·d) emodin peritoneal injection. 6 rats at each time spot (6 h,12 h,1 d,3 d,and 5 d after being treated) in each group were sacrificed to detect the serum concentration of neuron specific enolase (NSE) and to observe the number of NSE immunohistochemical positive cells in the cortex. Results Serum levels of NSE were obviously higher and the number of NSE immunohistochemical positive cells was significantly lower in model control group and emodin group than those in normal control group after cranio-cerebral explosive wound (P 0.01). Level of NSE was decreased and the number of NSE immunohistochemical positive cells was increased in emodin group as compared to model control group 1d after cranio-cerebral explosive wound(P 0.05). Conclusion Emodin can decrease serum level of NSE and increase the neuron expressing NSE,and presents a protective effect on cranio-cerebral explosive injury. 【" @default.
- W2357068699 created "2016-06-24" @default.
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- W2357068699 date "2009-01-01" @default.
- W2357068699 modified "2023-09-23" @default.
- W2357068699 title "Effect of emodin on neuron specific enolase in rat brain tissues after cranio-cerebral explosive wound" @default.
- W2357068699 hasPublicationYear "2009" @default.
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