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- W2357088124 abstract "Objective To observe the characteristics of coronary microvascular lesion (CML) in the autopsied elderly cases with hypertensive left ventricular hypertrophy (LVH) and the difference of CML among the groups of hypertension, coronary artery disease and diabetes under the condition of same LVH stage. Methods A retrospective study was performed in 206 cases over 60 years old of hypertension (HT), coronary artery disease (CAD) and diabetes (NIDDM) with LVH and 30 normal cases as control out of 3 195 consecutive autopsied cases from 1954 to 1996 in our hospital. The arteriole with the diameter of 10-60 μm and the capillary in muscular layer were shown by the methods of HE, Elastic fiber +VG staining and immunohistochemistry of CD31. Quantitative measurements on the arteriole density (AD), the ratio of arteriole wall and cavity (RWC), the capillary density (CD) and the area of endothelial cell (AEC) were performed by light microscope observation and image analysis by computer. According to the free wall thickness of left ventricle, the severity of LVH was divided into four degrees from 0 to Ⅲ, which was 0- Ⅲ degree in HT group and I degree respectively in CAD, HT+CAD and NIDDM groups. SAS system was used for the statistic analysis. Results The AD and RWC increased while CD and AEC decreased significantly with the aggravation of LVH in HT group (P0.05-0.01). There was a similar morphological change but in more severe degree in the group of HT+CAD compared with HT group (P0.01). The AD increased (P0.05), while RWC, CD and AED did not change significantly in CAD group. The AD increased, CD and AEC decreased (all P0.05), but RWC did not change very much in NIDDM groups. Conclusion The characteristics of CML in HT group was shown as increased AD and RWC, decreased CD and AEC, among which the increased RWC was the typical change compared with the groups of CAD and NIDDM. The damaged CML was one of the main causes for decreased coronary flow reserve and myocardial ischemia in cases of hypertensive LVH." @default.
- W2357088124 created "2016-06-24" @default.
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- W2357088124 date "2001-01-01" @default.
- W2357088124 modified "2023-09-23" @default.
- W2357088124 title "Characteristics of coronary microvascular lesion in the autopsied elderly cases with hypertensive left ventricular hypertrophy" @default.
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