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- W2357102016 abstract "Objective To find out the muhidrug resistant situation of Mycobacterium Tuberculosis in Changchun City in order to establish fast diction method according to the status in our country.Methods By modified Roche media,strains isolated between Jul 2004 to Dec 2007 were identified and the drug resistance was tested.PCR based reverse dot blot(RDB) and sequencing method were also used to analyze rpoB,rpsL,KatG and embB gene.Results The total multidrug resistant ratio of tuberculosis in Jilin Province is 32.96% among all the 625 strains;The drug resistance ratio is as follow:INH 18.17%、RIF 17.26%、SM 10.74%、EMB 7.31%.The ratio of retreated patients is higher than first treated ones.Among stochasticly selected strains,the RDB tested mutation rate of rpoB、rpsL,KatG and embB gene are 88.9%,83.3%,91.6% and 86.1% and compared rate with sequencing are 87.9%,87.9%,91.4% and 89.1%.Conclusion The drug resistant ratio in Changchun City is higher than that in the country and the situation has its own feature.The appearance of drug resistance has something to do with gene mutation.The situation is serious and need more restrict disease control strategy to avoid spread." @default.
- W2357102016 created "2016-06-24" @default.
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- W2357102016 date "2010-01-01" @default.
- W2357102016 modified "2023-09-23" @default.
- W2357102016 title "An Investigation on Multidrug Resistant status and gene detection of Mycobacterium Tuberculosis in Changchun City" @default.
- W2357102016 hasPublicationYear "2010" @default.
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