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- W2357108145 abstract "Objective: To develop and validate a sensitive and rapid hydrophilic interaction chromatography!tandem mass spectrometric(HILIC!MS / MS) method for the determination of salbutamol in human plasma after aerosol inhalation.Methods: Samples were prepared from plasma by protein precipitation using acetonitrile as the precipitation solvent;salbutamol and d9!salbutamol were separated on a Luna HILIC column(100 mm × 3.0 mm,3 μm) using acetonitrile(consisting of 0.1% formic acid)-5 mmol.L-1 ammonium acetate(pH 8.5 adjusted with ammonia water)(93∶ 7,v / v) as a mobile phase with isocratic elution.The injection volume was 2.0 μL,and a chromatographic total run time was 3.5 min.Mass spectrometry detection was conducted through electrospray ionization in positive ion multiple reaction monitoring modes,using the transitions of m / z 240 →(148 +166) and m/z 249 →(149 +167) for salbutamol and d9!salbutamol,respectively.Results: The method was linear over the concentration range of 11.7-2340 pg.mL-1 and the lower limit of quantification was 11.7 pg.mL-1.The intra-and inter day precision in terms of the relative standard deviation were less than 14.1%.The accuracy was in a range of ! 3.8% to !0.8% in terms of relative error.The method was successfully applied to pharmacokinetic evaluation study in healthy volunteers following inhalation of 200 μg salbutamol aerosol.Conclusion: The established HILIC-MS / MS method is sensitive,rapid and accuracy,which is suitable for the determination of salbutamol in human plasma and can detect the plasma concentration of 24 h post-dose." @default.
- W2357108145 created "2016-06-24" @default.
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- W2357108145 date "2013-01-01" @default.
- W2357108145 modified "2023-09-25" @default.
- W2357108145 title "Determination of salbutamol in human plasma after aerosol inhalation using hydrophilic interaction chromatography (HILIC)-tandem mass spectrometry" @default.
- W2357108145 hasPublicationYear "2013" @default.
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