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- W2357127498 abstract "Objective To evaluate the protective effects of the alcohol extract and water extract from Eucommia ulmoides on immunological liver-injury in mice induced by Bacille-Calmette-Guerin and lipopolysaccharide(BCG-LPS).Methods Mice were randomly divided into 9groups and 10 mice in each group,which were the normal group,model group,positive control group,3 dose alcohol extract group and 3 dose water extract group,6 test groups were given the ethanol or water extract at the dose of 40.95,81.90,163.80g/kg body weight,i.g once a day for 10 days,respectively,while positive group with bifendate(DDB)of 0.60g/kg b.w.in the same manner,and normal control and model control group with the same volume of distilled water.Immunological liver-injury model in mice was induced by BCG-LPS.The activities of ALT and AST in the serum,the content of MDA,and the activity of SOD,GSH in the liver cell were investigated.Results The ethanol extract from Eucommia ulmoides significantly decreased the level of ALT and AST in serum and the content of MDA in liver(P0.01),but improved SOD and GSH activities(P0.01)in the liver.Histologic examination indicated that most of liver cells were damaged after the treatment with BCG-LPS,but bifendate(DDB)and the extract from Eucommia ulmoides could significantly decreased the liver damage,but the effects of water extract were lower than the ethanol extract(P0.05).Conclusion The ethanol extract from Eucommia ulmoides could significantiy resist the immunological liver-injury." @default.
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- W2357127498 date "2011-01-01" @default.
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- W2357127498 title "Protective effects of the alcohol extract and the water extract from eucommia ulmoides oliver on immunological liver-injury in mice" @default.
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