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- W2357138553 abstract "Objective To observe the expression of related gene and protein in Hela cell apoptosis induced by 8-Br-cAMP,and to provide a new approach for the treatment of cervical cancer with 8-Br-cAMP.Methods The apoptosis percentage was detected by TUNEL method.The expression of related gene and protein was studied by the intact cell RNA dot blot,in situ hybridization and protein dot blot.Results In 8-Br-cAMP group the apoptosis percentage was (40.0±1.32)%,while in the control group it was (5.2±0.74)%,(P0.01).8-Br-cAMP up-regulated gene expression of wp53 and iNOS,P0.01. down-regulated gene expression of bcl-2,c-myc and mp53,P0.01,and enhanced iNOS and FasL activity,and decreased the Fas-IR.Conclusion 8-Br-cAMP could induce Hela cell apoptosis,and may be used as a new method for cervical cancer." @default.
- W2357138553 created "2016-06-24" @default.
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- W2357138553 date "2001-01-01" @default.
- W2357138553 modified "2023-09-24" @default.
- W2357138553 title "Study on Hela cell apoptosis induced by 8-Br-cAMP" @default.
- W2357138553 hasPublicationYear "2001" @default.
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