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- W2357138843 abstract "Objective To investigate the inhibition effect of taurine on cardiac fibroblasts proliferation,collagen synthesis and the ratio of collagens Ⅰ to Ⅲ.Methods Taurine was added in different dosage to the cultured cardiac Fbs.Culture media were collected.The synthesis of collagenous protein was determined by measuring hydroxyproline.The collagen type was subsequently analyzed by SDS PAGE,and the Fbs proliferation determined by MTT assay.Results Taurine(200 mmol/L at 24 h;100 mmol/L,200 mmol/L at 48 h;50 mmol/L at 72 h)could not only prevent the synthesis of collagen and the proliferation of the cardiac Fbs,but also reduce the ratio of collagens Ⅰ to Ⅲ.Conclusion Taurine could offer protection against the myocardial fibrosis by preventing the synthesis of collagen and reducing the ratio of collagens Ⅰ to Ⅲ." @default.
- W2357138843 created "2016-06-24" @default.
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- W2357138843 date "2004-01-01" @default.
- W2357138843 modified "2023-09-24" @default.
- W2357138843 title "Effect of taurine on the synthesis of collagen,proliferation of cardiac fibroblasts and the ratio of collagen I to III" @default.
- W2357138843 hasPublicationYear "2004" @default.
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