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- W2357146131 abstract "Objective To explore the feasibility and safety of intravenous injection of homologous bone marrow mesenchymal stem cells (MSC) for repairing injured myocardium and to observe homing and distribution of MSC in host.Methods Myocardial infarction was created by occluding the left anterior desending branch of coronary artery in Wistar rats.24 h after coronary artery occlusion,2×106/0.1 ml rMSCs labeled with 4',6'-diacetyl-2-phenylindole(DAPI) or 0.1 ml of culture medium as control were injected into the border zone of infarcted region. Four weeks after cell transplantation,the rats were sacrificed and histologic and immunohistochemical characteristics of the hearts were studied.Results Four weeks after transplantation, many DAPI-positive cells could be found in infarction and surrounding areas of the hearts. Immunohistochemical stainning revealed that the engrafted stem cells expressed both cTnI and desmin.There was no tumor growth in organs of cell-transplanted rats and no lymphocytes proliferation in myocardium sections.Conclusion Exogenous MSCs can play a beneficial role in repairing chronic myocardial infarction." @default.
- W2357146131 created "2016-06-24" @default.
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- W2357146131 date "2005-01-01" @default.
- W2357146131 modified "2023-09-23" @default.
- W2357146131 title "Intravenous administration of bone marrow mesenchymal stem cells for repairing acute myocardial infarction: feasibility and safety" @default.
- W2357146131 hasPublicationYear "2005" @default.
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