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- W2357157216 abstract "Objective To compare the therapeutic effects on patients with acute myocardial infarction(AMI) treated by primary percutaneous coronary intervention between early use of tirofiban and late use. Methods 60 AMI patients with emergency admission were divided into two groups: early group and late group. Tirofiban was infused at 10 μg/kg within 3 minute, followed by infusion at 0.15 μg·kg-1·min-1 for 24-36 h. TIMI,TMP, LVEF,platelet aggregation rate and bleeding in both groups were respectively compared and the adverse cardiovascular event in the hospital and 3-month follow-up were also observed. Results The TIMI 3 flow rate was significantly higher in the early group than that in the late group(36.7% vs 13.3%,P=0.037). However, there was no significant between two groups. TMP 2-3 rate in the early group, whether pro-procedural or post procedural, was higher than that in the late group(33.3% vs 10.0%,P=0.028, 83.3% vs 56.7%,P=0.024). Although EF in the both group increased after PCI [(52±8)% vs(42±6)%,P=0.005,(49±9)% vs (43±8)%,P=0.02], the difference of pro-procedural or post-procedural EF between the early group and the late one respectively was no significant. Platelet aggregation rate of post-procedural in the both were lower than that of pre-procedural[(44.7±14.5)% vs (53.9±17.7)%,P=0.033,(46.0±18.4)% vs (55.4±12.0)%,P=0.023]. The bleeding complication and MACE occurrence rate had no significant difference between 2 groups.Conclusion Early use of tirofiban in patients with AMI treated by primary PCI was effective and safe. Early use of tirofiban could improve significantly target vessels forward blood flow TIMI and myocardial blush TMP." @default.
- W2357157216 created "2016-06-24" @default.
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- W2357157216 date "2007-01-01" @default.
- W2357157216 modified "2023-09-24" @default.
- W2357157216 title "Effects of early use of tirofiban in patients with acute myocardial infarction on primary percutaneous coronary intervenion" @default.
- W2357157216 hasPublicationYear "2007" @default.
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