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- W2357174122 abstract "Objective To study the protection of the flavonoid of buckwheat Compound Preparation(TFBCP) against experimental diabetic cardiomyopathy in type 2 diabetes rats and its mechanism. Methods The SD rats were 70,12 were randomly selected in control group.The rests were built the Type 2 diabetes model.And then the models were randomly divided into 4 groups-L,H-TFBCP group,XKW group and model group.At the end of the experiment,the fasting blood glucose(FBG),the heart weight index(HWI:hw/bw) and the cardiac function were observed.Radioimmunoassay and Wetern-Blot techniques were used to measure P38α-mitogen activated protein kinases(P38α-MAPK) expression.Ventricular myocardium pathological changes were observed under light microscope. Results Compared with model group,TFBCP resulted in a dose-dependent decrease in FBG and HWI,improved cardiac function.TFBCP intervention group could inhibit the P38α-MAPK expression and activity displacement.Myocardium cells and myocardium's stroma changes in different dose of TFBCP groups were also significantly improved.The protection of H-TFBCP group was more effective,the role and XKW group were similar. Conclusion TFBCP has some protection on diabetic cardiomyopathy in type 2 diabetes rats.The mechanism may be related to inhibition of P38α-MAPK signal transduction system." @default.
- W2357174122 created "2016-06-24" @default.
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- W2357174122 date "2012-01-01" @default.
- W2357174122 modified "2023-09-26" @default.
- W2357174122 title "Effect of The Flavonoid of Buckwheat Compound Preparation on Diabetic Cardiomyopathy in Type 2 Diabetes Rats" @default.
- W2357174122 hasPublicationYear "2012" @default.
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