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- W2357177594 abstract "Objective:To develop a facile method for the preparation of β-amino acid enantiomers.Methods:The method was based on chiral separation by ligand-exchange flash chromatography and purification by solid-phase extraction.Firstly,synthetic racemates of β-amino acids were resolved into their enantiomers by chiral ligand-ex- change flash chromatography with L-hydroxyproline chemically bonded to irregular silica as the stationary phase and aqueous solution containing cupric ions as the mobile phase.The fractions containing β-amino acid enanti- omers were subjected to solid-phase extraction(SPE)with strong cation exchange resin and octadeeyl-bonded silica,respectively,to remove cupric ions present in the eluents.The effects of the composition,pH,and percentage of organic modifier of the eluting solution on removal of cupric ion and recovery of β-amino acid were examined. Results:Optimum conditions for chiral separation by ligand-exchange flash chromatography were 0.1 mol·L~(-1) cupric sulfate as eluting solution,4 mL saturation solutuion of amino acid as sample.Optimum conditions for removal of cupric ions by SPE purification were aqueous solution containing 0.1 mol·L~(-1)sodium chloride and 50% etha- nol,pH 3.0 for strong cation exchange resin and aqueous solution of 20% methanol,pH 3.0 for C_(18)chemically bonded silica.Conclusion:The ligand-exchange flash chromatography followed by solid-phase extraction is a via- ble method for preparation of β-amino acid enantiomers.The method is well suited for laboratory scale preparation as well as for industrial production." @default.
- W2357177594 created "2016-06-24" @default.
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- W2357177594 date "2007-01-01" @default.
- W2357177594 modified "2023-09-26" @default.
- W2357177594 title "Resolution and purification of β-amino acid enantiomers by ligand-exchange flash chromatography and solid-phase extraction" @default.
- W2357177594 hasPublicationYear "2007" @default.
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