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- W2357181551 abstract "Objective To observe the effect of ketamine pretreatment on stress ulcer in rats and the changes of nitric oxide (NO) and ulcer index (UI), and explore the possible mechanism of protection. Methods Forty rats were randomly divided into five groups, normal group (group N), stress ulcer group (group S), and ketamine groups (group K1, K2, and K3). The murine model of water immersion restraint stress was constructed. Six hours after stress, plasma and gastric mucosal NO levels were detected, UI was measured, the degree of gastric mucosa injury was observed grossly, and the histological changes were examined microscopically. Results As compared with group S, the degree of gastric mucosa injury was markedly declined in ketamine groups while plasma and gastric mucosal NO levels were obviously increased. Conclusion Ketamine pretreatment has a protective effect on stress ulcer, whose mechanisms may involve the capacity of ketmine to alter the levels of plasma and gastric mucosal NO." @default.
- W2357181551 created "2016-06-24" @default.
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- W2357181551 date "2008-01-01" @default.
- W2357181551 modified "2023-09-26" @default.
- W2357181551 title "Effect of ketamine pretreatment on stress ulcer in rats" @default.
- W2357181551 hasPublicationYear "2008" @default.
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