Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357181636> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2357181636 abstract "Objective To study the anagesic effect of compound brucine and its pharmacodynamics. Methods The mice were treated ip only once with compound brucine (32.6, 22.8, 16 mg/kg) and morphine (10 mg/kg) as positive control. Then the change of the latencies of licking paws on hot-plate were observed. The dose-effect and time-effect curves were studied. The apparent parameters of pharmacodynamics were estimated based on time-effect curves of compound brucine 32.6 mg/kg ip. Results Compound brucine can prolong the incubation period of pain caused by hot-plate in mice obviously. A significant dose-effect relationship was noted in the anagesic experenment. The potency of this drug (22.8, 16 mg/kg) ip was equivalent to that of the morphine 10 mg/kg ip. The time-effect curve after compound brucine 32.6 mg/kg ip was found to fit a 1-compartment open model with first order elimination. The apparent pharmacodynamic parameters were: Ka=0.09477/min, T1/2a=7.3 min, Ke=0.00203/min, T1/2e=341.4 min, Tb=1.3 min, Tmax=41.4 min, Emax=238.5, Te=598.7 min, Tc=597.4 min, respectively. Conclusion Compound brucine has remarkable analgesic effect with power potency and long duration." @default.
- W2357181636 created "2016-06-24" @default.
- W2357181636 creator A5067345023 @default.
- W2357181636 date "2005-01-01" @default.
- W2357181636 modified "2023-09-25" @default.
- W2357181636 title "Analgesia and Pharmacodynamics of Compound Brucine Injection in Mice" @default.
- W2357181636 hasPublicationYear "2005" @default.
- W2357181636 type Work @default.
- W2357181636 sameAs 2357181636 @default.
- W2357181636 citedByCount "0" @default.
- W2357181636 crossrefType "journal-article" @default.
- W2357181636 hasAuthorship W2357181636A5067345023 @default.
- W2357181636 hasConcept C111113717 @default.
- W2357181636 hasConcept C112705442 @default.
- W2357181636 hasConcept C185592680 @default.
- W2357181636 hasConcept C202751555 @default.
- W2357181636 hasConcept C2777389121 @default.
- W2357181636 hasConcept C2777725853 @default.
- W2357181636 hasConcept C2780723003 @default.
- W2357181636 hasConcept C2780813057 @default.
- W2357181636 hasConcept C2780820201 @default.
- W2357181636 hasConcept C55493867 @default.
- W2357181636 hasConcept C57992300 @default.
- W2357181636 hasConcept C71924100 @default.
- W2357181636 hasConcept C98274493 @default.
- W2357181636 hasConceptScore W2357181636C111113717 @default.
- W2357181636 hasConceptScore W2357181636C112705442 @default.
- W2357181636 hasConceptScore W2357181636C185592680 @default.
- W2357181636 hasConceptScore W2357181636C202751555 @default.
- W2357181636 hasConceptScore W2357181636C2777389121 @default.
- W2357181636 hasConceptScore W2357181636C2777725853 @default.
- W2357181636 hasConceptScore W2357181636C2780723003 @default.
- W2357181636 hasConceptScore W2357181636C2780813057 @default.
- W2357181636 hasConceptScore W2357181636C2780820201 @default.
- W2357181636 hasConceptScore W2357181636C55493867 @default.
- W2357181636 hasConceptScore W2357181636C57992300 @default.
- W2357181636 hasConceptScore W2357181636C71924100 @default.
- W2357181636 hasConceptScore W2357181636C98274493 @default.
- W2357181636 hasLocation W23571816361 @default.
- W2357181636 hasOpenAccess W2357181636 @default.
- W2357181636 hasPrimaryLocation W23571816361 @default.
- W2357181636 hasRelatedWork W1969237812 @default.
- W2357181636 hasRelatedWork W1991459690 @default.
- W2357181636 hasRelatedWork W2010659122 @default.
- W2357181636 hasRelatedWork W2020864065 @default.
- W2357181636 hasRelatedWork W2048982989 @default.
- W2357181636 hasRelatedWork W2071900434 @default.
- W2357181636 hasRelatedWork W2085603418 @default.
- W2357181636 hasRelatedWork W2089713777 @default.
- W2357181636 hasRelatedWork W2142322620 @default.
- W2357181636 hasRelatedWork W2151384659 @default.
- W2357181636 hasRelatedWork W2151591640 @default.
- W2357181636 hasRelatedWork W2337228209 @default.
- W2357181636 hasRelatedWork W2420222886 @default.
- W2357181636 hasRelatedWork W2442255505 @default.
- W2357181636 hasRelatedWork W2460779277 @default.
- W2357181636 hasRelatedWork W3180206893 @default.
- W2357181636 hasRelatedWork W49828255 @default.
- W2357181636 hasRelatedWork W2182134566 @default.
- W2357181636 hasRelatedWork W2402191010 @default.
- W2357181636 hasRelatedWork W3142965239 @default.
- W2357181636 isParatext "false" @default.
- W2357181636 isRetracted "false" @default.
- W2357181636 magId "2357181636" @default.
- W2357181636 workType "article" @default.