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- W2357183019 abstract "Objective To investigate the effects of SOD1 mutation -aggregation in amyotrophic lateral sclerosis (ALS) and to improve the understanding of the molecular mechanism of the disease. Methods To predict the effects of aggregation propensity with amino acid mutations, all known 106 missense mutations in SOD1 were collected and analyzed with 3 kinds of bioinformatics tools and methods, AGGRESCAN, PASTA and TANGO. Results The predicting outcome of 3 tools are similar and 39 mutations, accounting 37%, were considered to enhance the aggregation propensity. Conclusion The pathogenesis of ALS is supposed to be a multi-factors process. Protein aggregation caused by amino acid mutations is not the only important factor that amino acid mutations cause ALS disease." @default.
- W2357183019 created "2016-06-24" @default.
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- W2357183019 date "2009-01-01" @default.
- W2357183019 modified "2023-09-24" @default.
- W2357183019 title "Effects of Amyotrophic Lateral Sclerosis Associated SOD1 Amino Acid Mutations on Aggregation" @default.
- W2357183019 hasPublicationYear "2009" @default.
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