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- W2357184611 abstract "Objective To explore the molecular mechanisms potentially responsible for carcinogensis due to cadmium,the effects of cadmium-responsive oncoprotein(TEF-1δ encoded protein)on several different genes related to cellar tumors were investigated.Methods The expression of genes related to cellar tumo rs wer e detected by various monoclonal antibodies with stable transfection of mammalia n cells with TEF-1δ gene and by western blot analysis.Results All of the 4 different CHO cell lines stably expr essed very high levels of TEF-1δ encoded protein showed overexpression of cellu lar proto-oncogene c-fos,and the level of c-fos encoded protein(55 kDa) was very hig h as compared with stable-transfection of CHO cells with vector that was used as a control.All CHO cells which stably expressed very high level of TEF-1δ e ncoded protein demonstrated relatively high expression of cell cycle controlling g ene Cyclin D1(encoded 36 kDa protein)as compared with the vector control.There w ere no differences between CHO cell lines stably expressed very high levels of T EF-1δ encoded protein and the vector control cells for the other oncoproteins o f pan-ras,c-myc,c-jun,MDM2,ODC,p16,p53.Conclusion The translational up-regulation of cellular pr oto-oncogene c-fos and cell cycle controlling gene Cyclin D1 caused by overexpre ssion of the TEF-1δ,may be the molecular mechanism otentially responsible for carcinogenic potential of the novel cadmium-responsive proto-oncogen." @default.
- W2357184611 created "2016-06-24" @default.
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- W2357184611 date "2004-01-01" @default.
- W2357184611 modified "2023-09-23" @default.
- W2357184611 title "Effects of cadmium-responsive oncoprotein on cellar proto-oncogene gene expressi on" @default.
- W2357184611 hasPublicationYear "2004" @default.
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