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- W2357187025 abstract "Objective Study on immunocompetence and cytokine secretion of T lymphocytes infiltrating nasal polyps.Methods Nasal polyps tissues and peripheral blood from 45 patients with nasal polyps and inferior turbinate mucosa and peripheral blood from normal people were collected for the experiment,respectively.Flow cytometry was adopted to detect the expression of T cell surface markers(CD3, CD69) and serum production of Th cytokines(IL-4,IFN-γ).(1)Activation marker CD69 expressed highly in T cells from the nasal polyps and peripheral blood of patients,especially higher in T cells from the nasal polyps(P0.01). CD3+CD69+ T cells were rarely seen in the normal inferior turbinate mucosa and peripheral blood.(2)IL-4 and IFN-γ were detected in T cells from the nasal polyps and peripheral blood of the patients.CD3+IL-4+ and CD3+IFN-γ+ T cells were rarely detected in the normal inferior turbinate mucosa.Compared with in the normal people,the serum IL-4 and IFN-γ significantly increased in patients(P0.01).The IL-4 level was higher but the IFN-γ level was lower in the nasal polyps than those in the peripheral blood from the same patient(P0.01).Conclusion The T cells in nasal polyps express high CD69 and are activated,producing Th1/Th2 mixed cytokines with change of cytokine secretion predomination,probably owing to the formation of microenvironment of the nasal polyps and the mucosa immune system." @default.
- W2357187025 created "2016-06-24" @default.
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- W2357187025 date "2009-01-01" @default.
- W2357187025 modified "2023-09-27" @default.
- W2357187025 title "Study on immunocompetence and cytokine secretion of T lymphocytes infiltrating nasal polyps" @default.
- W2357187025 hasPublicationYear "2009" @default.
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