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- W2357193655 abstract "AIM: To compare the therapeutic efficacy and safety of two initial warfarin doses for atrial fibrillation(AF) and to further study the risk factors of hemorrhage.METHODS: A retrospective study was adopted.The inpatients with AF in recent 2 years were divided into two groups according to their initial warfarin doses: ultra-low dose group(1.25-1.875 mg) and low dose group(2.5-3.0 mg).The efficacy and safety of initial therapy of two groups were compared.Meanwhile,the major risk factors of bleeding were analyzed with logistic regression.RESULTS:There was no significant difference between two groups with respect to the safety(P0.05).However,the mean time to reach a therapeutic INR was significantly longer in the ultra-low dose group than that of low dose group(P0.05).In addition,the proportion of INR below the therapeutic range was much higher and the proportion of INR within the therapeutic range was much lower in ultra-low dose group than that of low dose group(P0.001).Elderly(age65 years),abnormal liver function,bleeding,stroke and amiodarone may increase the risk of hemorrhage significantly(OR1,P0.05).CONCLUSION: In the patients with AF,the ultra-low initial dosage has equal safety with regard to hemorrhage but increases the risk of thrombosis.At the same time,monitoring of the patients who combined amiodarone should be strengthened." @default.
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- W2357193655 date "2012-01-01" @default.
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- W2357193655 title "Investigation and analysis on initial warfarin dosage and hemorrhagic risk factors for atrial fibrillation" @default.
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