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- W2357217618 abstract "Objective To observe the regulating effect of sex hormone levels on spermatogenic cell apoptosis in male rats exposed to fluoride. Methods The fluorosis model was set up by peritoneal injection of NaF solution. The serum hormone levels were radioimmunochemically detected, and the apoptotic spermatogenic cells were quantitatively measured by TUNEL. Results ① Compared with control rats, administration of 10 and 20 mg·kg-1·(2 d)-1 NaF for 28 days could decrease serum testosterone level to(10.39±0.54),(8.34±1.29) nmol/L (P 0.05 or 0.01), respectively,the latter being(9.82±0.66),(6.33±0.68) nmol/L on day 38 (P 0.01), respectively. ② Compared with control rats, administration of 10 and 20 mg·kg-1·(2 d)-1 NaF for 28 days could decrease serum estradiol level to (44.24±11.32), (36.27±3.00) pmol/L (P 0.01), respectively, the later were lower, being (42.90±9.81),(26.02±16.14) pmol/L on day 38(P 0.01), respectively. ③ Compared with control rats, the apoptotic spermatogenic cell ratio of fluoride treatment group was significantly increased (P 0.01). ④ The apoptotic spermatogenic cell ratio was negatively correlated with serum testosterone level (r = - 0.901～- 0.886) and serum estradiol level (r = - 0.989～- 0.936). Conclusions Excessive fluoride results in disturbance of serum hormone levels, which is an important cause for spermatogenic cell apoptosis." @default.
- W2357217618 created "2016-06-24" @default.
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- W2357217618 date "2005-01-01" @default.
- W2357217618 modified "2023-09-26" @default.
- W2357217618 title "Regulating effect of sex hormone levels on spermatogenic cell apoptosis in male rats exposed to fluoride" @default.
- W2357217618 hasPublicationYear "2005" @default.
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