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- W2357223313 abstract "Objective To explore the protective effects and mechanism of transplantation of bone marrow mesenchymal stem cells(BMSCs) on central cholinergic system of rats with Alzheimer disease(AD).Methods Forty-five male Wistar rats were randomized into 3 groups(15 each) by using a random number table:fimbria-fornix(FF) transected model group(model group:AD model was established by bilateral hippocampal fimbria-fornix transection);sham group(SOC group:all the procedures but transection were the same as the model group);BMSCs transplantation group(BMSCs group:each rat was administered with 1×106 cells 2 weeks after AD model successfully established).Immunohistochemical assay and RT-PCR were used to detect the expression of choline acetyl transferase(ChAT) and mRNA expression of nerve growth factor(NGF) in the basal forebrain,respectively.Results In the 6th week after FF transection,the integral optical density value of ChAT expression was significatly lower in model group(1 249.71±143.25) than in SOC group(2 059.58±166.69,P0.05),and also in BMSCs group(1 807.02±133.85,P0.05).The mRNA expression was significantly lower in model group(0.45±0.08) than in SOC group(1.14±0.12,P0.05),and also in BMSCs group(0.78±0.09,P0.05).Conclusion BMSCs transplantation may have a protective effect on central cholinergic system in rats with AD,and NGF expression in basal forebrain may play a role in this effect." @default.
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- W2357223313 date "2009-01-01" @default.
- W2357223313 modified "2023-09-23" @default.
- W2357223313 title "Protective effects of transplantation of bone marrow mesenchymal stem cells on central cholinergic system in rats with Alzheimer disease" @default.
- W2357223313 hasPublicationYear "2009" @default.
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