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- W2357224020 abstract "Objective:To build an airway remodeling model of bronchial asthma in mouse with house dust mite extracts,to investigate the expressions of α-SMA in lungs,and clarificate the relationship between them.Methods:BALB/c mice were randomly divided into control group,HDM low-dose group and HDM high-dose group.Each group was randomly divided into three subgroups:three-week,six-week and nine-week group.The mice were challenged by intranasal drip after sensitized with subcutaneous and peritoneal injection of HDM with different doses.Technique of computer-assisted image analysis was used to detect the changes of the airway remodelling pathomorphology.The expressions of α-SMA in lungs were detected by immunohistochemistry(IH) and Real-time quantitative reverse transcription polymerase chain reaction(qRT-PCR).Results:Compared with control groups,in both high-dose HDM and low-dose HDM groups,the histopathological scores increased;the ratio of inner and outer diameter(D1/D2) was notably decreased;The expression of α-SMA protein and mRNA increased significantly;and all had changed severely with the prolongation of exposured time.Compared with high-dose HDM groups,low-dose groups changed lighter.Conclusion:The expression of α-SMA mRNA and protein in asthmatic mice airway remodeling induced by HDM was increased with the airway remodeling." @default.
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- W2357224020 date "2011-01-01" @default.
- W2357224020 modified "2023-09-25" @default.
- W2357224020 title "The expressions of α-SMA in airway remodeling model of bronchial asthma in mouse" @default.
- W2357224020 hasPublicationYear "2011" @default.
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