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- W2357228294 abstract "Objective To explore the mechanism of polypeptide from scorpion venom(PSV) on increasing the inhibition of 5-fluorouacil(5-Fu) on H 22 hepatoma.Methods H 22 hepatoma model was established through sc inoculating H 22 cells suspension into 40 mice in right armpits.Then tumor-bearing mice were divided into five groups randomly on the day 7 after inoculating: model,PSV(20 mg/kg),5-Fu(15 mg/kg),low-dose PSV(5 mg/kg) + 5-Fu,and high-dose PSV(20 mg/kg) + 5-Fu groups,10 mice in each group,continuously admininstered for 21 d.Tumor volumes were measured once every other day,then the curves of tumor growth were drawn and the tumor inhibitory rate was calculated;CD34 was used to mark capillary;Immunohistochemical assay was used to detect the protein expression changes of nuclear factor-kappa B(NF-κB),matrix metalloproteinase-9(MMP-9),and vascular endothelial growth factor(VEGF).Results Compared with the model group,the growth of H 22 hepatoma transplantation tumor in the combinational groups was obviously inhibited(P 0.01);The microvessel density(MVD) and the protein expression of NF-κB,MMP-9,and VEGF in the two PSV groups were all decreased significantly(P 0.01);Compared with 5-Fu group,the MVD and the protein expression of NF-κB,MMP-9,and VEGF in the high-dose PSV + 5-Fu group were also decreased(P 0.01),while there was no significant difference between the low-dose PSV + 5-Fu group.Conclusion PSV may increase the inhibition of 5-Fu on H 22 hepatoma through blocking NF-κB pathway and reducing the expression of MMP-9 and VGF,which is beneficial to the inhibition of angiogenesis." @default.
- W2357228294 created "2016-06-24" @default.
- W2357228294 creator A5061815085 @default.
- W2357228294 date "2013-01-01" @default.
- W2357228294 modified "2023-10-01" @default.
- W2357228294 title "Mechanism of polypeptide from scorpion venom increasing inhibition of 5-fluorouacil on H_(22) hepatoma" @default.
- W2357228294 hasPublicationYear "2013" @default.
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