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- W2357239761 abstract "Objective To investigate the relationship between the status of the TGFβR/Smads signal pathway in cancer cells and in its stromal cells,and if this may affect the development of endometrioid adenocarcinoma.Methods TGFβRⅠ,TGFβRⅡ,Smad2,Smad3,Smad4 and Smad7 were determined in hysteromyoma(12 cases) and endometrioid adenocarcinoma(18 cases) by the SP immunohistochemical method.Results TGFβRⅠ,TGFβRⅡ,Smad2,Smad3,Smad4 and Smad7 were found in hysteromyoma.TGFβR expression which was in positive correlation with Smads expression in normal endometrium cells(r=0.86,r=0.78).TGFβR/Smads expression disagreed in endometrial cancer cells and stromal cells and it was not found in stromal cells of endometrial adenocarcinoma per se.Conclusions TGFβR/Smads signals exist in cells of normal endometrial proliferative /secretory phase but its pathway is defected in tumor stroma.To get the information about TGFβR/Smads signal way in stroma probably provides a neotarget for gene therapy of endometrioid carcinoma." @default.
- W2357239761 created "2016-06-24" @default.
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- W2357239761 date "2008-01-01" @default.
- W2357239761 modified "2023-09-27" @default.
- W2357239761 title "Expression of TGFβR/Smads in endometrioid adenocarcinoma cancer cells and stromal cells" @default.
- W2357239761 hasPublicationYear "2008" @default.
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