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- W2357249320 abstract "Objective:To investigate the relationship between the expressions of vascular endothelial growth factor(VEGF),P53 protein and the microvessel density(MVD) and invasion,metastasis in salivary gland tumors.Methods: 54 cases of surgical specimens of salivary gland tumor from two hospitals were selected.Use immunohistochemical method to analyze the expressions of P53 protein,VEGF and MVD in three salivary gland tumors.Results:In 54 cases of salivary gland tumors,the positive rates of P53,VEGF and MVD in malignant gland tumors were significantly higher than that in benign salivary gland tumors(P0.05).The positive rates of P53,VEGF and the MVD were related to the nodal metastasis and the clinical substage(P0.05),and have no relation to the sites and sizes of the tumors.MVD in P53 and VEGF positive group was higher than that in their negative group(P0.05).Spearman rank correlation analysis showed that there was a positive corelation between VEGF and MVD.The same results were found between VEGF and P53,P53 and MVD.Conclusion: P53 and VEGF,MVD play a key role in occurrence and development of salivary gland tumor,and serve as an indicator of malignancy and development of salivary gland tumor.P53,VEGF and MVD may be served as the predicators for the biological behavior and the prognostic factor of salivary gland tumor.p53 gene might play important role in promoting tumor angiogenesis." @default.
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- W2357249320 date "2009-01-01" @default.
- W2357249320 modified "2023-09-23" @default.
- W2357249320 title "The expressions of vascular endothelial growth factor,P53 protein and microvessel density in salivary gland tumor and its clinical significance" @default.
- W2357249320 hasPublicationYear "2009" @default.
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