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- W2357279079 abstract "Objective To observe the effects of different types of antihypertensive drugs on activities of Na~+,K~+-ATPase,Ca~(2+)-ATPase and autocrine of AngⅡin vascular smooth muscle cells (VSMC) isolated from spontaneously hypertensive rats(SHR).Methods The thoracic aorta VSMC isolated from SHR were cultured.The cultured aorta VSMC were treated with different types of antihypertensive drugs:lisinopril,amlodipine,irbesartan,metoprolol and hydrochlorothiazide. The activities of ion pumps were detected by spectrophotometry and the content of AngⅡin cell-culture medium was detected by radioimmunoassay.Results The activities of Na~+,K~+-ATPase and Ca~(2+)-ATPase in aorta VSMC from SHR were significantly lower than those from Wistar-Kyoto rats(P0.01);lisinopril and irbesartan significantly increased the activities of the two ion pumps in aorta VSMC from SHR(P0.01).Amlodipine only increased the activities of Na~+,K~+-ATPase,but metoprolol and hydrochlorothiazide had no effects on them.Lisinopril and amlodipine attenuated the content of AngⅡin aorta VSMC from SHR(P0.05),but irbesartan increased it(P0.05).Conclusion Lisinopril,amlodipine and irbesartan can increase the activities of Na~+,K~+-ATPase and(or) Ca~(2+)-ATPase and influence the autocrine of AngⅡin aorta VSMC from SHR." @default.
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- W2357279079 date "2011-01-01" @default.
- W2357279079 modified "2023-09-23" @default.
- W2357279079 title "Effects of antihypertensive drugs on activities of ion pumps and autocrine of Ang II in hypertensive rats" @default.
- W2357279079 hasPublicationYear "2011" @default.
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