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- W2357287613 abstract "Aim To design and synthesize N arylsulfonyl α alkyl L amino acid esters,and to study their in vitro neurotrophic activities.Methods Based on the former work,a series of N arylsulfonyl α alkyl L amino acid esters was designed and synthesized according to the biological isosterism.Results 32 target compounds were synthesized and their structures were determined by 1H NMR and MS.Conclusion Compounds 3,5,10,12,13,14,15,20,21 and 28 exerted potent enhancement of the effects of NGF for promoting the survival of PC12 cells;And,compounds 12,13,15,20 and 28 displayed good augmentation on neurite outgrowth in the chick dorsal root ganglion cultures,of them,compound 12 and 15 exhibited higher activities than GPI 1046." @default.
- W2357287613 created "2016-06-24" @default.
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- W2357287613 date "2002-01-01" @default.
- W2357287613 modified "2023-09-25" @default.
- W2357287613 title "Synthesis and neurotrophic activities of N-arylsulfonyl α-alkyl L-amino acid esters" @default.
- W2357287613 hasPublicationYear "2002" @default.
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