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- W2357290434 abstract "Objective To explore the reversal effects of XDNF1-0425 and XDNF8-0113 on Doxorubicin resistance in human breast cancer cell line MCF-7/ADR in vitro. Methods GENMED phosphodiesterase5(PDE5) activity assay kit was used to detect the inhibition of two kinds of sildenafil homologues to PDE5. MTT assay was used to determine the cell growth inhibiting ratio of human breast cancer cell line MCF-7 and MCF-7/ADR cells after treated by Sildenafil, XDNF1-0425, XDNF8-0113, Doxorubici(DOX) or Doxorubici(DOX) plus Sildenafil homologues. Further more, figured out each inhibitive concentration 50(IC50) of DOX. The expression of P-gp was determined with Western blot. Results It showed that the two kinds of homologues(XDNF1-0425 and XDNF1-0113) have weaker inhibitory activity of PDE5 than the sildenafil. The sensitivity of MCF-7/ADR to DOX was significantly increased by XDNF1-0425 and XDNF1-0113 in a dose-dependent manner(P0.05). The sensitivity of MCF-7/ADR to DOX was significantly increased with a reversal fold of 6.36/5.58 by 10 μmol·L-1 XDNF1-0425/XDNF1-0113, and even increased with a reversal fold of 11.83/13.47 by 20 μmol·L-1 XDNF1-0425/XDNF1-0113. Western blot results showed that both homologues had no effect on the expression of protein. Conclusion The two Sildenafil homologues have a weaker inhibitory activity. Certain concentration of Sildenafil homologues could effectively reverse Doxorubicin resistance in human breast cancer cell line MCF-7/ADR in vitro." @default.
- W2357290434 created "2016-06-24" @default.
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- W2357290434 date "2014-01-01" @default.
- W2357290434 modified "2023-09-23" @default.
- W2357290434 title "Effects of Two Novel Compounds on the Drug Resistance of MCF-7/ ADR cell to Doxorubicin" @default.
- W2357290434 hasPublicationYear "2014" @default.
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