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- W2357312983 abstract "Objective:To observe the effects of TCM from the lung therapy and from the intestine therapy on the level of TGF-β1 in rats with Crohn's disease.Methods:The rat model of Crohn's disease was established by TNBS and ethanol enema.The model rats were experimentally treated with from the lung therapy decoction(Huangqijiegeng Decoction),from the intestine therapy decoction(Huangqihuanglian Decoction),and western medicine SASP,respectively,by gastric perfusion.And the changes in the level of TGF-β1,TGF-β1 mRNA in colon and lung,the level of TGF-β1 in blood serum of rats with crohn's disease were respectively detected at the period of time of zero and three weeks after the treatment.Results:In the zero week,the level of TGF-β1 and TGB-β1 mRNA in colon and lung in model group,the level of TGB-β1 in blood serum was significantly increased compared with that in normal control group(P0.01).Three week after treatment,model group was still significantly increased compared with that in normal control group(P0.01),and in different treating group the level of TGF-β1 was significantly decreased compared with that in model group(P0.01,P0.05).The level of TGF-β1 of intestine in SASP group was decreased than model group(P0.05),but there was obvious differences between SASP group and normal control group either(P0.01);and lower than the level of from-intestine therapy group(P0.05).There was no obvious difference between from the intestine therapy group and from the lung therapy group compared with normal control group.The level of TGB-β1 mRNA of lung in SASP group and from the intestine therapy group was decreased compared with that in model group(P0.01),but there was obvious difference between them and normal control group(P0.01).There was no obvious difference between from the lung therapy group and normal control group,but there was obvious differences between the SASP groupand form the intestine group(P0.05).The level of TGF-β1 in blood serum was decreased in different treating groups compared with model group,but there was obvious difference with normal control group(P0.01,P0.05),from the intestine therapy group decreased significantly than from the lung therapy group(P0.01).Conclusion:All of the three kinds of medicine including from-lung therapy decoction(Huangqijiegeng Decoction),from-intestine therapy decoction(Huangqihuanglian Decoction) and sulfasalazine could decrease the expression of TGF-β1 in rats with crohn's disease.From the intestine therapy decoction had an advantage in relieving the inflammatory reaction and preventing intestinal fibrosis.From the lung therapy decoction had an advantage in relieving inflammatory reaction in lung and preventing pulmonary fibrosis." @default.
- W2357312983 created "2016-06-24" @default.
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- W2357312983 date "2013-01-01" @default.
- W2357312983 modified "2023-09-28" @default.
- W2357312983 title "Comparison between effects of TCM from the lung therapy and from the intestine therapy on the level of TGF-β1 in rats with Crohn's disease" @default.
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