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- W2357318635 abstract "Objective To set up a standard experimental model of defect at rabbit femoral shaft which can not heal up spontaneously. Methods Anatomic data of rabbit femur were obtained through measurement in order to guide the operation. Then bone defects of 10, 15, and 20 mm were made respectively in the femoral shafts of 18 grown New Zealand rabbits. The defects were fixed by common plates. Radiography, DXA (Dual Energy X-ray Absorptiometry), general observation and histology were undertaken to examine bone formation at time points of 4, 8, 12 weeks. Results The rabbit femur had a length of 94.1 mm. At the midpiece of the rabbit femoral shaft, the transverse diameter was 7.4 mm and the sagittal diameter 5.8 mm. At the same place, cortical bone was the thickest at the posterior side and the thinnest at the anterior. The thickness of 2 lateral sides was between the 2 extremes above. The average thickness of cortical bone was 1.2 mm. The average diameter of the medullary cavity was 4.1 mm while the sagittal diameter was 1.0 mm less than the transverse one. The bone defects in the 10 mm group of rabbit femoral shaft healed up in 8 to 12 weeks. No recovery of bone defect in the 15mm group was seen after 12 weeks as not in the 20 mm group. Conclusions Bone defects of 15 mm and more in rabbit femoral shaft can not heal up spontaneously. Consequently, this critical-sized segmental bone defect model may be used for the research of bone tissue engineering." @default.
- W2357318635 created "2016-06-24" @default.
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- W2357318635 date "2005-01-01" @default.
- W2357318635 modified "2023-09-26" @default.
- W2357318635 title "An experimental model of bone defect at the rabbit femoral shaft to be used in bone tissue engineering research" @default.
- W2357318635 hasPublicationYear "2005" @default.
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