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- W2357319902 abstract "Metabonomics,a newly emerging omics science in postgenomics era,is an important part of system biology.By means of non-targeting quantitative determination of various low-molecular-weight metabolites in bio-specimen,it enables a better understanding of the metabolic variation in organisms when subject to internal and external stimuli.As the result,it is particularly suitable for characterizing the metabonomic alternation associated with various factors,such as genetics,growth,physiology,environment and stimuli of xenobiotics and pathogeny.Not only can metabonomics describe the state and alteration of organism’s metabolic function during the development and treatment of diseases,providing a novel approach to diagnosing diseases,explor-ing into the pathologic mechanism,and even offering new therapeutic targets,but can also reveal metabonomic effect of outside factors such as drugs/toxins,environment,diets and lifestyles,and thus facilitates therapeutic evaluation of medicines and identifying etiology of diseases.In general,recently metabonomics has been widely employed in clinical research,achieves fruitful results and shows exciting perspective.This article reviews the progress of metabonomics applying to clinic research,including the description of disease state,development of diagnostic methods,exploration of etiology,pathogeny and pathology as well as assessment of pharmacodynamics." @default.
- W2357319902 created "2016-06-24" @default.
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- W2357319902 date "2010-01-01" @default.
- W2357319902 modified "2023-09-23" @default.
- W2357319902 title "The application of metabonomics to clinical research and the progress" @default.
- W2357319902 hasPublicationYear "2010" @default.
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