Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357323557> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2357323557 abstract "Objective:To explore the protective effect of biochanin A(Bioch A) on lipopolysaccharide(LPS) -induced dopaminergic neurodegeneration. Method:An in vitro model of LPS-induced dopaminergic neurodegeneration was used to investigate the protective effect of Bioch A on dopaminergic neurons against LPS-induced neurotoxicity by measuring [3H] DA uptake and counting TH-immunoreactive cells. Microglia were visualized by staining for the CR3 complement receptor with monoclonal antibody OX-42. The production of nitric oxide(NO) was determined by measuring the accumulated levels of nitrite in the culture supernatant with the Griess reagent,and release of tumor necrosis factor-α(TNF-α) was measured by immunosorbent assay. The production of superoxide was determined by measuring the superoxide dismutase(SOD) -inhibitable reduction of cytochrome C. Results:BiochA dose-dependently attenuated LPS-induced decrease in dopamine(DA) uptake and the number of dopaminergic neurons in rat mesencephalic neuron-glia cultures. BiochA also significantly inhibited LPS-induced activation of microglia and production of TNF-α,NO and superoxide in rat mesencephalic neuron-glia cultures and microglia-enriched cultures. Conclusion:Biochanin A may protect dopaminergic neurons from LPS-induced injury and its effectiveness in inhibiting microglia activation may underlie one of the mechanisms." @default.
- W2357323557 created "2016-06-24" @default.
- W2357323557 creator A5009542579 @default.
- W2357323557 date "2007-01-01" @default.
- W2357323557 modified "2023-09-28" @default.
- W2357323557 title "BIOCHANIN A PROTECTS DOPAMINERGIC NEURONS BY INHIBITING MICROGLIA ACTIVATION" @default.
- W2357323557 hasPublicationYear "2007" @default.
- W2357323557 type Work @default.
- W2357323557 sameAs 2357323557 @default.
- W2357323557 citedByCount "0" @default.
- W2357323557 crossrefType "journal-article" @default.
- W2357323557 hasAuthorship W2357323557A5009542579 @default.
- W2357323557 hasConcept C126322002 @default.
- W2357323557 hasConcept C134018914 @default.
- W2357323557 hasConcept C137183658 @default.
- W2357323557 hasConcept C178790620 @default.
- W2357323557 hasConcept C17991360 @default.
- W2357323557 hasConcept C185592680 @default.
- W2357323557 hasConcept C203014093 @default.
- W2357323557 hasConcept C2776914184 @default.
- W2357323557 hasConcept C2776925932 @default.
- W2357323557 hasConcept C2778298627 @default.
- W2357323557 hasConcept C2778821405 @default.
- W2357323557 hasConcept C2779134260 @default.
- W2357323557 hasConcept C2779491297 @default.
- W2357323557 hasConcept C2779830541 @default.
- W2357323557 hasConcept C2780955279 @default.
- W2357323557 hasConcept C29730261 @default.
- W2357323557 hasConcept C513476851 @default.
- W2357323557 hasConcept C519581460 @default.
- W2357323557 hasConcept C71924100 @default.
- W2357323557 hasConcept C86803240 @default.
- W2357323557 hasConcept C98274493 @default.
- W2357323557 hasConceptScore W2357323557C126322002 @default.
- W2357323557 hasConceptScore W2357323557C134018914 @default.
- W2357323557 hasConceptScore W2357323557C137183658 @default.
- W2357323557 hasConceptScore W2357323557C178790620 @default.
- W2357323557 hasConceptScore W2357323557C17991360 @default.
- W2357323557 hasConceptScore W2357323557C185592680 @default.
- W2357323557 hasConceptScore W2357323557C203014093 @default.
- W2357323557 hasConceptScore W2357323557C2776914184 @default.
- W2357323557 hasConceptScore W2357323557C2776925932 @default.
- W2357323557 hasConceptScore W2357323557C2778298627 @default.
- W2357323557 hasConceptScore W2357323557C2778821405 @default.
- W2357323557 hasConceptScore W2357323557C2779134260 @default.
- W2357323557 hasConceptScore W2357323557C2779491297 @default.
- W2357323557 hasConceptScore W2357323557C2779830541 @default.
- W2357323557 hasConceptScore W2357323557C2780955279 @default.
- W2357323557 hasConceptScore W2357323557C29730261 @default.
- W2357323557 hasConceptScore W2357323557C513476851 @default.
- W2357323557 hasConceptScore W2357323557C519581460 @default.
- W2357323557 hasConceptScore W2357323557C71924100 @default.
- W2357323557 hasConceptScore W2357323557C86803240 @default.
- W2357323557 hasConceptScore W2357323557C98274493 @default.
- W2357323557 hasLocation W23573235571 @default.
- W2357323557 hasOpenAccess W2357323557 @default.
- W2357323557 hasPrimaryLocation W23573235571 @default.
- W2357323557 hasRelatedWork W1860952316 @default.
- W2357323557 hasRelatedWork W1891696008 @default.
- W2357323557 hasRelatedWork W1965455421 @default.
- W2357323557 hasRelatedWork W1966288885 @default.
- W2357323557 hasRelatedWork W1978276060 @default.
- W2357323557 hasRelatedWork W2008010082 @default.
- W2357323557 hasRelatedWork W2039190334 @default.
- W2357323557 hasRelatedWork W2065696410 @default.
- W2357323557 hasRelatedWork W2076636473 @default.
- W2357323557 hasRelatedWork W2091713828 @default.
- W2357323557 hasRelatedWork W2153527716 @default.
- W2357323557 hasRelatedWork W2198673487 @default.
- W2357323557 hasRelatedWork W2198776700 @default.
- W2357323557 hasRelatedWork W2350465813 @default.
- W2357323557 hasRelatedWork W2370606983 @default.
- W2357323557 hasRelatedWork W2469215375 @default.
- W2357323557 hasRelatedWork W2886141103 @default.
- W2357323557 hasRelatedWork W3032154944 @default.
- W2357323557 hasRelatedWork W3203531887 @default.
- W2357323557 hasRelatedWork W3208291514 @default.
- W2357323557 isParatext "false" @default.
- W2357323557 isRetracted "false" @default.
- W2357323557 magId "2357323557" @default.
- W2357323557 workType "article" @default.