Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357332557> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2357332557 abstract "AIM:To investigate the in vitro killing effect of adenovirus-mediated herpes simplex virus thymidine kinase gene(HSV-TK) driven by hypoxic response element(HRE) on hepatoma cell line HepG2.METHODS:Recombinant adenoviral vector Ad-HRE-TK was constructed with HSV-TK under the control of HRE using AdEasy system.Then Ad-HRE-TK was transfected into hepatoma cell line HepG2 and the cells were cultured under normoxic or hypoxic conditions.After treated with GCV for 3 d,the sensitivity to GCV of HepG2 was measured by MTT method.RESULTS:Over 95% HepG2 cells infected with Ad-HRE-TK cultured under hypoxic condition were killed when the MOI was 100 and the concentration of GCV was 50 mg/L.On the contrary,no killing effect of GCV was observed in cells cultured under normoxic condition.CONCLUSION:HRE promotes the expression of HSV-TK specifically under hypoxic condition and induces the specific killing effect of GCV." @default.
- W2357332557 created "2016-06-24" @default.
- W2357332557 creator A5082848722 @default.
- W2357332557 date "2009-01-01" @default.
- W2357332557 modified "2023-09-26" @default.
- W2357332557 title "In vitro killing effect of adenovirus-mediated herpes simplex virus thymidine kinase gene under regulation of hypoxic response element on hepatoma cell line HepG2" @default.
- W2357332557 hasPublicationYear "2009" @default.
- W2357332557 type Work @default.
- W2357332557 sameAs 2357332557 @default.
- W2357332557 citedByCount "0" @default.
- W2357332557 crossrefType "journal-article" @default.
- W2357332557 hasAuthorship W2357332557A5082848722 @default.
- W2357332557 hasConcept C104317684 @default.
- W2357332557 hasConcept C111599444 @default.
- W2357332557 hasConcept C153911025 @default.
- W2357332557 hasConcept C159047783 @default.
- W2357332557 hasConcept C202751555 @default.
- W2357332557 hasConcept C2522874641 @default.
- W2357332557 hasConcept C2776147627 @default.
- W2357332557 hasConcept C2781196997 @default.
- W2357332557 hasConcept C32470452 @default.
- W2357332557 hasConcept C40767141 @default.
- W2357332557 hasConcept C54009773 @default.
- W2357332557 hasConcept C54355233 @default.
- W2357332557 hasConcept C55493867 @default.
- W2357332557 hasConcept C81885089 @default.
- W2357332557 hasConcept C86803240 @default.
- W2357332557 hasConceptScore W2357332557C104317684 @default.
- W2357332557 hasConceptScore W2357332557C111599444 @default.
- W2357332557 hasConceptScore W2357332557C153911025 @default.
- W2357332557 hasConceptScore W2357332557C159047783 @default.
- W2357332557 hasConceptScore W2357332557C202751555 @default.
- W2357332557 hasConceptScore W2357332557C2522874641 @default.
- W2357332557 hasConceptScore W2357332557C2776147627 @default.
- W2357332557 hasConceptScore W2357332557C2781196997 @default.
- W2357332557 hasConceptScore W2357332557C32470452 @default.
- W2357332557 hasConceptScore W2357332557C40767141 @default.
- W2357332557 hasConceptScore W2357332557C54009773 @default.
- W2357332557 hasConceptScore W2357332557C54355233 @default.
- W2357332557 hasConceptScore W2357332557C55493867 @default.
- W2357332557 hasConceptScore W2357332557C81885089 @default.
- W2357332557 hasConceptScore W2357332557C86803240 @default.
- W2357332557 hasLocation W23573325571 @default.
- W2357332557 hasOpenAccess W2357332557 @default.
- W2357332557 hasPrimaryLocation W23573325571 @default.
- W2357332557 hasRelatedWork W2036663141 @default.
- W2357332557 hasRelatedWork W2349099236 @default.
- W2357332557 hasRelatedWork W2357791870 @default.
- W2357332557 hasRelatedWork W2361908794 @default.
- W2357332557 hasRelatedWork W2365880288 @default.
- W2357332557 hasRelatedWork W2367844470 @default.
- W2357332557 hasRelatedWork W2369229074 @default.
- W2357332557 hasRelatedWork W2374917988 @default.
- W2357332557 hasRelatedWork W2376759682 @default.
- W2357332557 hasRelatedWork W2377064085 @default.
- W2357332557 hasRelatedWork W2378190229 @default.
- W2357332557 hasRelatedWork W2394389626 @default.
- W2357332557 hasRelatedWork W2411438516 @default.
- W2357332557 hasRelatedWork W2412932801 @default.
- W2357332557 hasRelatedWork W2425753625 @default.
- W2357332557 hasRelatedWork W2426089984 @default.
- W2357332557 hasRelatedWork W3030811012 @default.
- W2357332557 hasRelatedWork W3140553079 @default.
- W2357332557 hasRelatedWork W3141323554 @default.
- W2357332557 hasRelatedWork W332791991 @default.
- W2357332557 isParatext "false" @default.
- W2357332557 isRetracted "false" @default.
- W2357332557 magId "2357332557" @default.
- W2357332557 workType "article" @default.