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- W2357337391 abstract "AIM To investigate the effects of dexamethasone (DM) and glycyrrhizin (GL) on the hepatocyte apoptosis caused by phenobarbital (PB) withdrawal in mice. METHODS The ratio of liver/body weight, hepatic DNA content, morphological changes and TUNEL reaction (TdTmediated XdUTP nick labeling) as indices of evaluating hepatocyte apoptosis, were used to observe the effects of DM (9 mgkg-1, ip) and GL (50 mgkg-1, ip) on the hepatocyte apoptosis caused by PB withdrawal. RESUITS The regression of hepatic DNA content and ratio of liver/body weight and typical hepatocyte apoptosis, which occured in the control as mice after stopping PB treatment, were not found in the mice treated with DM, and a negative result of TUNEL assay was presented. However, in the mice given GL the ratio of liver/body weight and hepatic DNA content regressed by 120% and 136%, respectively; with a positive reaction of TUNEL assay and the typical changes of hepatocyte apoptosis. CONCLUSION The results showed that DM, but not GL, preve" @default.
- W2357337391 created "2016-06-24" @default.
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- W2357337391 date "1999-01-01" @default.
- W2357337391 modified "2023-09-25" @default.
- W2357337391 title "Effects of dexamethasone and glycyrrhizin on the hepatocyteapoptosis caused by phenobarbital withdrawal in mice" @default.
- W2357337391 hasPublicationYear "1999" @default.
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