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- W2357355043 abstract "Objective To study the effect of vanadium(V) combined with Vit D3 for the treatment of xenografted lolon cancer in nude mouse. Methods After establishment of the xenografted lolon cancer model,the mice were randomly divided into 4 groups with 25 mice each.The mice in group A were administered V(200mg·kg-1·d-1)by lavage,in group B Vit D3(2U·kg-1·d-1) by intramuscular injection,in group C V(200mg·kg-1·d-1) by lavage combined with Vit D3(2U·kg-1·d-1) by intramuscular injection,and in group D normal sodium(200ml·kg-1·d-1) by intramuscular injection as the negative controls.Four weeks later,18 mice from each group were killed,the gross tumor volume and numbers of metastatic nodules were measured.PCNA index of tumors were assayed by immunohistochemistry.The rast of mice in each group were used to evaluate the survival time.Apoptosis of tumor cells and tumor cells cycle were analyzed by flow cytometry when all mice died. Results Compeared with group D,the PCNA index of tumor cells was less and survival time of mice was longer and apoptosis rate of tumor cells was increased in group C (P0.05).Tumor cells were arrested in G0 /G1 phase as well.Conclusion Vanadium combined with Vit D3 significantly reduces the proliferation and induces the apoptosis of colon cancer cells." @default.
- W2357355043 created "2016-06-24" @default.
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- W2357355043 date "2009-01-01" @default.
- W2357355043 modified "2023-09-24" @default.
- W2357355043 title "Therapeutic effects of vanadium combined with vitamin D_3 on the xenografted colon cancer in BALB/C nude mouse" @default.
- W2357355043 hasPublicationYear "2009" @default.
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