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- W2357361307 abstract "Objective To explore the effects of all trans retinoicacid(ATRA) on iNOS expression of colon carcinoma cell lines with different proliferation potentials. Methods MTT was used to detect the growth and reproduction of colon cancer cell lines CW-2 and LS174T, Northern blot and RT-PCR were used to detect expression of iNOSmRNA in colon carcinoma; Western blot was used to detect protein expression of iNOS. Results Colon cancer cell line LS174T grows and reproduces faster than CW-2; iNOS mRNA was expressed in both CW-2 and LS174T cell lines with a higher expression of iNOS mRNA in CW-2 cell lines: ATRA had no obvious effect on iNOS mRNA expression in CW-2 and LS174T cell lines. Conclusion iNOS had dual effect on proliferation of colon carcinoma cell lines, with high expression in low-proliferation CW-2, and low expression in high-proliferation LS174T.ATRA inhibits the growth of colon carcinoma cell lines, with no obvious influence on expression of iNOS mRNA and protein." @default.
- W2357361307 created "2016-06-24" @default.
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- W2357361307 date "2004-01-01" @default.
- W2357361307 modified "2023-09-26" @default.
- W2357361307 title "Effects of all trans retinoic acid on iNOS expression of colorectal carcinoma cell lines with different proliferation potentials" @default.
- W2357361307 hasPublicationYear "2004" @default.
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