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- W2357361792 abstract "Objective Shock induced dispersion of repolarization (SIDR) measured by multiple monophasic action potential (MAP) recordings and its relashingship to the induction of ventricular fibrillation (VF) by T wave shocks were studied. Methods Biphasic shocks (65/65% tilt,5 ms duration) were delivered to Langendorff perfused rabbit hearts at shock coupling intervals (CI) ranging from 150～220 ms and shock strengths (SS) ranging from 140～540V.Ten MAPs were recorded simultaneously from 8 epicardial and 2 endocardial sites from both ventricles to assess SIDR at multiple sites.SIDR was defined as the difference between the longest and shortest shock induced MAP response. Results VF induction was associated with high SIDR (64±15) ms.There was a significant decrease in SIDR as shock coupling intervals moved outside the borders of the vulnerable window (VW)[(33±14) ms left of the VW and (27±8) ms right of the VW,both P 0.001].For shocks within the VW,SIDR significantly decreased when SS reached values at or above the upper limit of vulnerability (ULV) [(41±17) ms, P 0.01] Conclusion T wave shocks which induce VF are associated with a high degree of SIDR." @default.
- W2357361792 created "2016-06-24" @default.
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- W2357361792 date "1999-01-01" @default.
- W2357361792 modified "2023-09-25" @default.
- W2357361792 title "Shock induced dispersion of repolarization is essential for the induction of ventricular fibrillation by T wave shocks" @default.
- W2357361792 hasPublicationYear "1999" @default.
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