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- W2357365008 abstract "Objective:To observe the immune protection of matrine ( Mat) on a rat model of chronic Pseudomonas aeruginosa ( PA) biofilm pneumonia.Method:Rats were challenged intratracheally with alginate embedded PA strain PAO579 in the concentration of 1×109 colony-forming units per milliliter(CFU·mL-1).Mat or sterile normal saline (NS) was injected intraperitoneally once a day for two weeks starting on the second day after challenge.Two weeks post intratracheal challenge with PA,parameters were evaluated.Result:Two weeks after challenge,the Mat-treated group showed a significantly milder pathological changes in lung(P0.001),and lower lung abscess incidence compared to the model group( P0.001).Furthermore,a remarkable improved bacterial clearance(P0.001) and a shift from an acute type to a chronic type of lung inflammation were found in the Mat-treated group compared to the model group.80% animals have returned to a chronic type of lung inflammation after Mat treatment which were much higher than that in the model group(P0.05).The lung cells from the Mat-treated group produced more interferon-gamma(IFN-γ)(P0.001),but less interlerkin-4(IL-4)(P0.001)as compared to the model group.These results indicate that Mat has an effect of inducing Th1 type of immune response.Conclusion:Mat treatment significantly reduced pathological changes in lung and enhanced lung bacterial clearance,which might be associated with a shift of local immune responding type from a Th2 like to Th1 like.This might provide a better immune protection to the rats with chronic P.aeruginosa bilfilm lung infection." @default.
- W2357365008 created "2016-06-24" @default.
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- W2357365008 date "2010-01-01" @default.
- W2357365008 modified "2023-09-25" @default.
- W2357365008 title "Effects of Matrine on Immune Protection in A Rat Model of Chronic Pseudomonas aeruginosa Biofilm Pneumonia" @default.
- W2357365008 hasPublicationYear "2010" @default.
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