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- W2357366869 abstract "OBJECTIVE:To investigate the expression of vascular endothelial growth factor in colorectal carcinoma and colorectal adenoma and normal colorectal tissues by using immunohistochemistry,and evaluate the relationship between VEGF expression,development and metastasis of colorectal cancer.METHODS:The expression levels of VEGF was assessed by immunohistochemistry SP method in 89 colorectal cancer samples.Totally 22 colorectal adenoma samples and 26 normal colorectal samples.Then the correlation between the expression of VEGF and the clinicopathological characters of colorectal cancer were investigated.RESULTS:The positive rate of VEGF in colorectal carcinoma(71.9%,64/89) was much higher than that in normal colorectal tissue(30.8%,8/26) and colorectal adenoma(40.9%,9/22),and there was a statistical among difference them(P0.01).Furthermore the expression of VEGF in colorectal carcinoma was significantly correlated with the Dukes stage of tumor and lymph node metastasis and the patient's age(P0.05),and no correlation was observed with the histological grade and the patient's gender.CONCLUSION:Improved VEGF expression is associated with the occurence,development,infiltration and lymph node metastasis of colorectal carcinoma,and VEGF can be an effective marker for judging the invasiveness and prognosis of colorectal carcinoma." @default.
- W2357366869 created "2016-06-24" @default.
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- W2357366869 date "2010-01-01" @default.
- W2357366869 modified "2023-09-23" @default.
- W2357366869 title "Expression and significance of vascular endothelial growth factor in colorectal benign and malignant tumors" @default.
- W2357366869 hasPublicationYear "2010" @default.
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