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- W2357366939 abstract "Objective To study the correlation of polymorphisms with CYP1A1,CYP2E1 RsaI and GSTM_1 independently and in corrbination with the risk of lung cancer.Methods A case control study which included 91 cases of lung cancer and 91 controls collected from the hospital.Blood samples were collected from all cases and controls for detecting CYP1A1,CYP2E1 RsaI and GSTM_1 polymorphisms which were analyzed by PCR and RELP.Results Compared with the m_1m_1 genotype of CYP1A1,OR of the m_2m_2 genotype of CYP1A1 was 1.51(0.76～3.01),OR of the m_1m_2 genotype of CYP1A1 was 0.84(0.41～1.72).Compared with the C_1C_2 genotype of CYP2E1,OR of the C_1C_1 genotype of CYP2E1 was 1.80(0.95-3.40),and those of the C_2C_2 genotype was 5.48(1.21～25.23).Comparing with the GSTM_1(+/+)genotype,OR of the GSTM_1(0/0) was 1.26(0.69-2.30).The results of analysis of the corrbination of two genetic polymerphisms showed that the people of CYP1A1 and GSTM_1 null(0/0) had 2.29(0.92～9.97) who carried out m_2m_2 genotype fold risk of developing lung cancer compared with those who carried out m_1m_1 genotype of CYP1A1 and GSTM_1(+/+) genetype.Compared with GSTM_1(+/+) genotype with C_1C_2 genotype of CYP2E1,OR of GSTM_1 null(0/0) with C_1C_1 genotype of CYP2E1 was 2.13(0.82～5.56).But there was no statistical significance(P0.05).Compared with those carrying m_1m_1 genotype of CYP1A1 and C_1C_2 genotype of CYP2E1,the people with m_2m_2 genotype of CYP1A1 and the C_1C_1 genotype of CYP2E1 increased in risk of lung cancer,the OR was 3.00(1.03～8.78).The results of analysis of the corrbination of three genetic polymerphisms showed that people carrying m_2m_2 genotype of CYP1A1,C_1C_1 genotype of CYP2E1 and GSTM_1 null(0/0) had higher risk of lung cancer than those with the other genotypes of this three genetic polymerphisms,OR was 3.97(0.94～16.79).Conclusion Polymorphism of a single gene of CYP1A1,CYP2E1,and GSTM_1 was not associated with the risk of lung cancer.The corrbination of two or more genetic polymerphisms might increase the risk of lung cancer,but there was no statistic significance.The three gene polymorphisms investigated were of minor importance susceptibility markers for lung cancer in this population." @default.
- W2357366939 created "2016-06-24" @default.
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- W2357366939 date "2005-01-01" @default.
- W2357366939 modified "2023-09-24" @default.
- W2357366939 title "Case control study on relationship between lung cancer and its susceptibility marker" @default.
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