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- W2357367746 abstract "Ropivacaine hydrochloride was synthesized from(S)-2-pipecolic acid by successive reaction with SOCl2 and 2,6-dimethylaniline under ultrasonic irradiation to yield(S)-N-(2,6-dimethylphenyl)-piperidin-2-carboxamide(Ⅴ),which went through a subsequent reaction with 1-bromopropane under ultrasonic irradiation.The effects of reaction solvent,temperature and duration under ultrasonic irradiation were investigated.Compared with conventional methods,the present procedures have the advantages of milder conditions,shorter reaction duration and higher yields.The optimal conditions of the synthesis of ropivacaine hydrochloride were as follows:toluene being used as solvent in acylation and amidation reaction,acylation reaction conditions of 40 ℃ for 1.5 h,propyl reaction conditions of 40 ℃ for 1 h.Under such optimum reaction conditions,the total yield was 57.8%,and [α]25D=-6.7°(c2,H2O).Some of the intermediates and the target product were characterized by means of melting point and 1HNMR." @default.
- W2357367746 created "2016-06-24" @default.
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- W2357367746 date "2012-01-01" @default.
- W2357367746 modified "2023-09-23" @default.
- W2357367746 title "Synthesis of Ropivacaine Hydrochloride Under Ultrasonic Irradiation" @default.
- W2357367746 hasPublicationYear "2012" @default.
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