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- W2357383203 abstract "Objective To investigate whether glial cell line - derived neurotrophic factor (GDNF) combined with neurotro-phin - 3 (NT - 3) provides the synergetic protection on hair cells (HC) from acoustic trauma. Methods Guinea pigs were ex-posed to a 4 kHz narrow band noise at 115 dB SPL for 4 hrs. The left cochlea of the animals was infused with artificial peril-ymph (AP) containing (the test group) or without containing (the control group) a mixture of GDNF (100 ng/ml) and NT - 3(2. 5μg/ml) via a mini - osmotic pump connected to the scala tympani. The infusion began at 4 days before the noise exposureand continued for 10 days after the noise exposure. Hearing function was assessed by measuring the thresholds of auditorybrainstem responses (ABRs) elicited by clicks, before and 3 days after the osmotic pump implantation, and repeated 10 daysafter the noise exposure (14 days after the pump implantation). The numbers of damaged OHCs were quantitatively assessed bystaining with rhodamine - phalloidin for F - actin in the cuticular plates and with Hoechst 33342 for HC nuclei. Results Therewas a statistically significant increase in the number of survived out hair cell (OHC) (p0.001, p0.01) and a decrease inABR threshold shifts (p0.05, p0.01) in both treated (left) and untreated (right) ears of animals received GDNF and NT- 3. Conclusion These findings indicate that GDNF combined with NT - 3 can effectively protects OHCs from noise - induceddamage." @default.
- W2357383203 created "2016-06-24" @default.
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- W2357383203 date "2003-01-01" @default.
- W2357383203 modified "2023-09-27" @default.
- W2357383203 title "Neurotrophins decrease degeneration of out hair cells of the guinea pig after noise trauma" @default.
- W2357383203 hasPublicationYear "2003" @default.
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