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- W2357383690 abstract "Objective:To identify the clinical features and prognostic factors of kidney cancer patients with bone metastases.Methods:We retrospectively analyzed the data from 45 kidney cancer patients with bone metastases who were treated in our hospital between Jan 1997 and Jan 2007.Multiple prognostic factors were analyzed such as age,gender,tumor size,resection of primary lesions,radiation of primary lesions,number of bone lesions,serum alkaline phosphatase(ALP)level,parenchyma metastases,lymph node metastases,and normal organ metastases.Survival time was calculated by using the Kaplan-Meier method.Univariate analysis was performed using log-rank method and multivariate analysis was conducted using COX regression model.Results:The 1-,2-,and 3-year survival rates were 54.0%,26.0% and 17.3% respectively for kidney cancer patients with bone metastasis and the median survival time was(14.0±1.8)months.Univariate analysis showed that there was significant difference in the survival rate between serum ALP level ≤150 u/L and 150 u/L group(P=0.001).Other parameters had no prognostic value.COX multivariate analysis showed that serum ALP levels at the time of bone metastasis,normal organ or lymph node metastases were independent prognostic factors.Conclusion:The kidney cancer patients with bone metastases has poor prognosis.The serum ALP level,normal organ metastases or lymph node metastases were independent prognostic factors.These prognostic factors will help to determine the appropriate plan and dose of fractionated radiotherapy." @default.
- W2357383690 created "2016-06-24" @default.
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- W2357383690 date "2010-01-01" @default.
- W2357383690 modified "2023-09-28" @default.
- W2357383690 title "Clinical features and prognostic factors of kidney cancer patients with bone metastases" @default.
- W2357383690 hasPublicationYear "2010" @default.
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