FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357391966> ?p ?o ?g. }

• W2357391966 endingPage "985" @default.
• W2357391966 startingPage "979" @default.
• W2357391966 abstract "DNA double-strand breaks are repaired through either non-homologous end joining (NHEJ) or homologous recombination repair (HRR) pathway. The well-characterized regulatory mechanisms of double-strand break repair (DSBR) are mainly found at the level of complicated repair protein interactions and modifications. Regulation of DSBR at the transcriptional level was also reported. In this study, we found that DSBR can be regulated by miR-34a at the post-transcriptional level. Specifically, miR-34a, which can be activated by DNA damages, represses DSBR activities by impairing both NHEJ and HRR pathways in cultured cells. The repression is mainly through targeting the critical DSBR promoting factor SIRT1, as ectopically expressed SIRT1 without 3′-UTR can rescue the inhibitory roles of miR-34a on DSBR. Further studies demonstrate that SIRT1 conversely represses miR-34a expression. Taken together, our data show that miR-34a is a new repressor of DSBR and the mutual inhibition between miR-34a and SIRT1 may contribute to regulation of DNA damage repair." @default.
• W2357391966 created "2016-06-24" @default.
• W2357391966 creator A5030429211 @default.
• W2357391966 creator A5038885141 @default.
• W2357391966 creator A5042995444 @default.
• W2357391966 creator A5046052996 @default.
• W2357391966 creator A5054815138 @default.
• W2357391966 creator A5064970312 @default.
• W2357391966 creator A5075889094 @default.
• W2357391966 date "2012-12-21" @default.
• W2357391966 modified "2023-10-18" @default.
• W2357391966 title "Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair" @default.
• W2357391966 cites W1969408132 @default.
• W2357391966 cites W1975437957 @default.
• W2357391966 cites W1990623204 @default.
• W2357391966 cites W2000536447 @default.
• W2357391966 cites W2002456707 @default.
• W2357391966 cites W2004326614 @default.
• W2357391966 cites W2004736524 @default.
• W2357391966 cites W2006173503 @default.
• W2357391966 cites W2014396605 @default.
• W2357391966 cites W2014553510 @default.
• W2357391966 cites W2017270642 @default.
• W2357391966 cites W2030166934 @default.
• W2357391966 cites W2036270526 @default.
• W2357391966 cites W2037723157 @default.
• W2357391966 cites W2038167014 @default.
• W2357391966 cites W2041081715 @default.
• W2357391966 cites W2050863525 @default.
• W2357391966 cites W2059848983 @default.
• W2357391966 cites W2060768223 @default.
• W2357391966 cites W2068476548 @default.
• W2357391966 cites W2074210527 @default.
• W2357391966 cites W2074343204 @default.
• W2357391966 cites W2074699503 @default.
• W2357391966 cites W2074766088 @default.
• W2357391966 cites W2083158631 @default.
• W2357391966 cites W2083381199 @default.
• W2357391966 cites W2103770333 @default.
• W2357391966 cites W2111655556 @default.
• W2357391966 cites W2144154026 @default.
• W2357391966 cites W2146176862 @default.
• W2357391966 cites W2147477441 @default.
• W2357391966 cites W2161222316 @default.
• W2357391966 cites W2171296186 @default.
• W2357391966 cites W2317412573 @default.
• W2357391966 cites W2335538541 @default.
• W2357391966 doi "https://doi.org/10.1007/s11434-012-5599-8" @default.
• W2357391966 hasPublicationYear "2012" @default.
• W2357391966 type Work @default.
• W2357391966 sameAs 2357391966 @default.
• W2357391966 citedByCount "3" @default.
• W2357391966 countsByYear W23573919662016 @default.
• W2357391966 countsByYear W23573919662018 @default.
• W2357391966 countsByYear W23573919662022 @default.
• W2357391966 crossrefType "journal-article" @default.
• W2357391966 hasAuthorship W2357391966A5030429211 @default.
• W2357391966 hasAuthorship W2357391966A5038885141 @default.
• W2357391966 hasAuthorship W2357391966A5042995444 @default.
• W2357391966 hasAuthorship W2357391966A5046052996 @default.
• W2357391966 hasAuthorship W2357391966A5054815138 @default.
• W2357391966 hasAuthorship W2357391966A5064970312 @default.
• W2357391966 hasAuthorship W2357391966A5075889094 @default.
• W2357391966 hasBestOaLocation W23573919661 @default.
• W2357391966 hasConcept C102744134 @default.
• W2357391966 hasConcept C104317684 @default.
• W2357391966 hasConcept C122917832 @default.
• W2357391966 hasConcept C134935766 @default.
• W2357391966 hasConcept C150194340 @default.
• W2357391966 hasConcept C153911025 @default.
• W2357391966 hasConcept C158448853 @default.
• W2357391966 hasConcept C186310378 @default.
• W2357391966 hasConcept C54355233 @default.
• W2357391966 hasConcept C552990157 @default.
• W2357391966 hasConcept C86339819 @default.
• W2357391966 hasConcept C86803240 @default.
• W2357391966 hasConcept C95444343 @default.
• W2357391966 hasConceptScore W2357391966C102744134 @default.
• W2357391966 hasConceptScore W2357391966C104317684 @default.
• W2357391966 hasConceptScore W2357391966C122917832 @default.
• W2357391966 hasConceptScore W2357391966C134935766 @default.
• W2357391966 hasConceptScore W2357391966C150194340 @default.
• W2357391966 hasConceptScore W2357391966C153911025 @default.
• W2357391966 hasConceptScore W2357391966C158448853 @default.
• W2357391966 hasConceptScore W2357391966C186310378 @default.
• W2357391966 hasConceptScore W2357391966C54355233 @default.
• W2357391966 hasConceptScore W2357391966C552990157 @default.
• W2357391966 hasConceptScore W2357391966C86339819 @default.
• W2357391966 hasConceptScore W2357391966C86803240 @default.
• W2357391966 hasConceptScore W2357391966C95444343 @default.
• W2357391966 hasIssue "9" @default.
• W2357391966 hasLocation W23573919661 @default.
• W2357391966 hasOpenAccess W2357391966 @default.
• W2357391966 hasPrimaryLocation W23573919661 @default.
• W2357391966 hasRelatedWork W160849336 @default.
• W2357391966 hasRelatedWork W1974083655 @default.
• W2357391966 hasRelatedWork W1994621278 @default.
• W2357391966 hasRelatedWork W2018991595 @default.

• next