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- W2357403735 abstract "The adhesion properties of both hepatocytes and hepatocellular carcinoma cells(HCCs) onto the Coll Ⅳ/laminin coated surface were measured by means of micropipitte aspiration technique.Furthe,relevance of microfilament and microtubule systems to the adhesion properties of the HCCs on coll Ⅳ/laminin coated dishes were investigated by using cytoskeletal agents colchicine and cytochalasin D.The results showed:cytochalasin D,which inhibits microfilament polymerization,had great inhibitory effect on adherence of both kinds cell to Coll Ⅳ/Laminin substratum (about 70%~90%).Colchichine,which inhibits microtubular polymerization,had different effects on both cells:Compared with untreated groups,the adhesion forces of HCC cells decreased and those of hepatocytes increased.These data suggested that,in these tumor cells,microfilaments are crucial for adherence,and abnornal cytoskeletons of tumor cells may be basis of their abnormal adhesion properties." @default.
- W2357403735 created "2016-06-24" @default.
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- W2357403735 date "2000-01-01" @default.
- W2357403735 modified "2023-09-25" @default.
- W2357403735 title "Relevance of the Cytoskeleton System to the Adhesion Properties of the HCC Cells" @default.
- W2357403735 hasPublicationYear "2000" @default.
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