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- W2357413235 abstract "Objectives To develop a scientific and economical degenerative disc animal model for the study on the intervertebral disc.Methods The bipedal rats model was developed in 152 neonatal SD rats by forelimb amputation and special breeding methods.Ten normal rats in the same age served as the control.When the rats in the two groups were 18 months old,the L_ 2-3 disc was removed and observed under light and electron microscopy after the rats were sacrificed.Results After forelimb amputation,the bipedal rats grew well.Eighteen months after the operation,17 bipedal rats survived.Light microscopy revealed that the degeneration of the nucleus pulposus and annulus fibrosus was severe in bipedal rats' discs.Lumbar disc herniation was found in 2 bipedal rats.By ultrastructural examination on nucleus pulposus,obvious degeneration and necroses were found in the notochordal cells.Many fat drops were found in chondrocytelike cells.The collagen fibers in the matrix were irregular;large numbers of lamellar structures and mass appeared.Degeneration of the discs of the normal rats was gentle,and the arrangement of collagen fibers was in order.Conclusion This method of developing the animal model of disc degeneration is economical and easy.The degeneration procedure of the bipedal rats' discs is in agreement with that of human beings." @default.
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- W2357413235 date "2004-01-01" @default.
- W2357413235 modified "2023-09-25" @default.
- W2357413235 title "The development of a degenerative disc animal model in bipedal rats" @default.
- W2357413235 hasPublicationYear "2004" @default.
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