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- W2357413771 abstract "Objectire:To study therapeutic effect of cinepazide malate for chronic cerebral circulation insufficiency (CCCI). Methods:Cinepazide malate was injected with CCCI in a dose of 160 mg/day for 14 days in 80 patients. The peak of velocity(VP),resistance index (RI)of middle cerebral artery(MCA) and vertebral artery(VA) were studied with TCD. The levels of plasma malonic aldehyde and superoxide dismutase (SOD) were determined with chromatomety, the levels of endothelin(ET) and calcitonin gene-related peptide(CGRP)were determined with radioim-munological assay(RIA) pre- and post-therapy.Results:Following cinepazide malate treatment for 14 days, the total effective rate for dizziness, top- heaviness and in-somnia was 98.8%, 93.2% and 86.4% respectively.Plasma MDA, ET and RIs were lower post-therapy than that pre -therapy(P0.01).SODand CGRP were higher pos-therapy than that pre-therapy(P0.01).Conclusion:Cinepazide malate was very effective for CCCI. Cinepazide malate could reduce the content of plasma MDA and ET, increase the activity of SOD as well as promote the release of CGRP." @default.
- W2357413771 created "2016-06-24" @default.
- W2357413771 creator A5045191344 @default.
- W2357413771 date "2007-01-01" @default.
- W2357413771 modified "2023-09-27" @default.
- W2357413771 title "Therapeutic effect of cinepazide maleate in treatment of 80 cases with chronic cerebral circulation insufficiency" @default.
- W2357413771 hasPublicationYear "2007" @default.
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