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- W2357416310 abstract "Objective: To investigate the effect of Astragalus mongholicus on the expression of monocyte chemoattractant protein-1(MCP-1) in acute Coxsackievirus B3(CVB3) murine myocarditis.Methods: A total of 55 BALB/c mice were assigned into three groups: normal control group(group A,n=15),CVB3 infected group(group B,n=20),and Astragalus mongholicus treated group(group C,n=20).The mice in group B and C were inoculated with 0.15 ml of TCID50 10-9/L CVB3,while mice in group A were inoculated with 0.15 ml of Eagle's reagent.The mice in group C were treated with Astragalus mongholicus [10 g/(kg·d)] from 1st day to 14th day postinfection.After all of the mice were sacrificed on the 14th day,electronic microscopy were used to detect the inflammation and necrosis in myocardium.The expressions of MCP-1 in myocardium were determined by immunohistochemistry and by RT-PCR.Results: The survival rate of mice treated mice with Astragalus mongholicus increased.Compare to group A,group B had much more expression of MCP-1,which had a significantly positive correlation with myocardium histopathologic scores(r=0.87,P0.01).The histopathologic scores and the expression of MCP-1 in myocardium of group C were significantly lower than those in the myocardium of group B(both P0.01).Conclusion: Astragalus mongholicus can effectively reduce the myocardical injury and the expression of MCP-1 in the experimental CVB3 myocarditis." @default.
- W2357416310 created "2016-06-24" @default.
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- W2357416310 date "2009-01-01" @default.
- W2357416310 modified "2023-09-25" @default.
- W2357416310 title "Effect of Astragalus Mongholicus on the Expression of Monocyte Chemoattractant Protein-1 in Acute Coxsackievirus B_3 Murine Myocarditis" @default.
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