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- W2357426780 abstract "To study the association of TLR2,4/MyD88 pathway molecules mRNA in inflammation,a mouse model with acute colitis was induced.Six mice were killed respectively for 0,1,3,5 and 7 day old.The mRNA expression levels of TLR2,TLR4,MyD88,NF-κB,TNF-α and IL-10 were detected by quantitative real-time reverse-transcriptase polymerase chain reaction.The results showed that,compared with the 0 day group,the transcription level of TLR2 mRNA was significantly high on 3,5 days(P0.05),and its expression was a significantly difference on 3,5 day old(P0.001);1 day old after were induced,the expression of TLR4 was up-regulated significantly(P0.05),and it was more abnormal expression on 3,5 and 7 day old(P0.001);MyD88 and NF-κB mRNA were increased rapidly on 5,7 day old(P0.01);it showned that TNF-α was high expression at all stages(excepting one day old)(P0.01 or P0.001);the transcription level of IL-10 rised sharply in the first day(P0.001),since then it reduced gradually but its expression level were still higher than the previous of induction.TLR2/4 possibly through up-regulate mRNA expressions of MyD88,NF-κB and TNF-α,but down-regulate the transcription level of IL-10 mRNA to contribute to the inflammatory response." @default.
- W2357426780 created "2016-06-24" @default.
- W2357426780 creator A5025047624 @default.
- W2357426780 date "2012-01-01" @default.
- W2357426780 modified "2023-09-23" @default.
- W2357426780 title "Expression and Significance of TLR2,4/MyD88 Pathway Molecules mRNA in Colonic Mucosa of Mice Model with Induced Acute Colitis" @default.
- W2357426780 hasPublicationYear "2012" @default.
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