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- W2357429271 abstract "OBJECTIVE: To evaluate the efficacy and safety of domestic capsules of calcium dobesilate in the treatment of diabetic retinopathy (DR) or diabetic nephropathy (DN).METHOD: A multi-center, double-blind, randomized, parallel, with imported(Ebewe Arzneimittel GmbH,Austria) controlled clinical trial in the patients with DR or DN. Patients randomized in the test group or in the control group were assigned to receive 500mg of domestic calcium dobesilate or imported twice daily for 12 weeks in the patients with DR or for 4 weeks in whom with DN. While other patients with varix of lower limb or piles were assigned to receive 500mg of domestic calcium dobesilate for 2 weeks.RESULTS: A total of 164 cases were evaluable for the final analysis in which 30 cases (51 eyes) with DR were in the test group, 30 cases (53 eyes) with DR were in the control group, while 34 cases with DN were in the test group and 34 cases with DR were in the control group. 1). DR: According to the test of sight, numbers of microangioma of fundus of eye, bleeding area and leakage area of fundus of eye, the mean total score of the left andright eye of the test group are 6.66 ± 2.34 (n=25) and 6.58 ± 2.04 (n=26) separately, while those of the left and right eye of the control group are 6.20 ± 1.84 (n=27) and 6.42 ± 1.68 (n=26) separately. There is no significant difference between the two groups. 2). DN: UAER decreased by 26.7% and 26.3% in the test group and in the control group separately. There is no significant difference between the two groups. 3). Varix of lower limb: The circumference of the patients ankle decreased from 26.0 ±4.2 to 24.3 ± 3.3cm after treatment (P0.01). There is no liver or kidney damage been found. The proportion of patients reporting adverse experiences was comparable between two groups.CONCLUSIONS: Our data suggests that domestic calcium dobesilate can be used in treating DR and DN which is as effective and safe as treatment with the same dosage of imported." @default.
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- W2357429271 date "2002-01-01" @default.
- W2357429271 modified "2023-09-24" @default.
- W2357429271 title "Clinical Efficacy of Calcium Dobesilate in the Treatment of Diabetic Retinopathy and Nephropathy: A Phase Two Clinical Trial in Chinese Population" @default.
- W2357429271 hasPublicationYear "2002" @default.
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