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- W2357435997 abstract "AIM: To investigate the expression of Smad ubiquitin regulatory factor 2 ( Smurf 2) and transcription co-repressor Ski-related protein N ( SnoN) in renal tissues of diabetic rats,and to explore the effect of the E3 ubiquitin ligase Smurf 2 on the protein level of SnoN. METHODS: The rat model of diabetes was induced by vena caudalis injection of streptozotocin ( STZ) . The rats were killed at week 2,4,8,12,16,and 24 after injection of STZ. Meanwhile, the age-matched rats without any treatment served as normal controls ( n = 6) . The blood glucose,serum creatinine ( Scr) and 24-hour urine protein were examined by biochemical method. The kidney index of the rats was also measured. The pathological changes of the pancreatic and renal tissues were stained with HE and observed under microscope. The expression levels of insulin,Smurf 2,SnoN,TGF-β1 and phosphorylation of Smad2 were determined by immunofluorescence staining and/or Western blotting. The mRNA expression of Smurf 2 and SnoN in renal cortex was examined by RT-PCR. RESULTS: Compared with the control animals,the blood glucose,24-hour urine protein,Scr and kidney index increased remarkably in diabetic rats. The expression of insulin in control groups was strong,whereas that in diabetic groups was weak. The proteins of Smurf 2 and SnoN detected by immunofluorescence staining were located in the renal tubules. The protein levels of TGF-β1,Smurf 2 and p-Smad2 were significantly up-regulated in diabetic rats. The renal SnoN protein of diabetic rats at the time point of week 2 was the same as that of the normal rats; however,a significant decrease was observed from the time point of week 4 after DM induction. No significant difference of SnoN mRNA level was observed between normal and diabetes groups at all time points. The mRNA level of Smurf 2 was gradually up-regulated in the diabetic rats. CONCLUSION: Downregulation of SnoN protein in renal tissues of diabetic rats may be mediated by Smurf 2." @default.
- W2357435997 created "2016-06-24" @default.
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- W2357435997 date "2010-01-01" @default.
- W2357435997 modified "2023-09-28" @default.
- W2357435997 title "Expression of Smurf 2 in kidney of diabetic rats and its relationship with downregulation of SnoN" @default.
- W2357435997 hasPublicationYear "2010" @default.
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